Helicobacter pylori infection
Conditions
Interventions
Vonoprazan-containing triple therapy test group:Vonoprazan 20mg bid, Amoxicillin 1000mg tid, Metronidazole 400mg tid
empiric bismuth quadruple therapy control group:Esomeprazole 20mg bid. Bismuth 220mg bid. Amoxicillin 1000mg tid. Metronidazole 400mg tid
Sponsors
Shanghai East Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Male or female patients aged 18-70 years; 2. Patients diagnosed as Hp positive by gastroscopy with a positive rapid urease test, who have never received previous HP eradication treatment; 3. Patients with gastroscopically confirmed gastritis or inactive peptic ulcer; 4. Those who have not used antibiotics, bismuth, H2RA, PPI, P-CAB, etc. for 8 weeks prior to treatment; 5. Signed informed consent form and informed of the specific trial protocol.
Exclusion criteria
Exclusion criteria: 1. Patients with failed H. pylori eradication; 2. Pregnant, lactating women; 3. history of malignant tumors of the gastrointestinal tract; 4. history of previous major gastrectomy; 5. severe insufficiency of vital organs such as heart, liver, kidney and lung and congenital diseases; e.g. class IV cardiac insufficiency, liver failure, uremia, respiratory failure, hemophilia, Wilson's disease, etc.; 6. Those who are allergic to the drugs used; 7. refusal of the guardian or patient to be enrolled; 8. persons with alcohol and/or drug abuse (addiction or dependence) or poor compliance as judged by the physician; 9. Persons with legal incapacity or poor self-awareness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of side effects;Resistance rate of H. pylori;Compliance rate;Change in symptom scores;Reinfection rate; | — |
Countries
China
Contacts
Public ContactYingjie Ji
Shanghai East Hospital
Outcome results
None listed