Depression,insomnia
Conditions
Interventions
Healthy control group:No processing
Sertraline Group:Oral sertraline
Acupuncture group (oral sertraline + the acupuncture method of consolidating the essence and regulating the mind):oral sertraline + the acupuncture method of consolidating the essence and regulating t
Sham needle group (oral sertraline+ sham needle):oral sertraline + sham needle
Pure True Acupuncture Group:Acupuncture treatment. The patient was placed in supine position, and the acupoints used were Baihui, Shenting, Hegu, Taichong, Zhonghe, Xiahe, Qihai and Guanyuan, and the
Pure Sham Acupuncture Group:Disposable flat-tipped acupuncture needles (0.25 mm × 25 mm) were used. The operation points were the same as those of the simple real acupuncture group. The bottom of the
Sponsors
Shenzhen Baoan District Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patient inclusion criteria ? Meet the diagnostic criteria for depression in Western medicine; ? Also meet the diagnostic criteria of insomnia in the International Classification of Sleep Disorders, Third Edition (ICSD-3); ? Sex is not limited, age 18 to 60 years old, junior high school (including) and above (clinical efficacy observation is not limited to gender; in order to exclude gender-induced differences in immune patterns, the mechanism study part is only for non-menopausal women aged 18 to 45 years old); ? 7 points = 8, meeting diagnostic criteria for primary insomnia; ? Those who signed the informed consent form and voluntarily participated in this study; 2. Healthy control group inclusion criteria: ? Non-menopausal females aged 18-45 years old with junior high school (including) or higher education; ? HAMD17 score <=7; (iii) Pittsburgh Sleep Quality Index (PSQI) score < 8 points. ? No history of chronic diseases such as hypertension and heart disease; ? No recent use of anti-inflammatory drugs such as amoxicillin.
Exclusion criteria
Exclusion criteria: 1. HAMD17 score > 24; 2. Suicidal person; 3. with other acute or chronic inflammatory diseases; 4. previous diagnosis of suicidal ideation, schizophrenia, bipolar disorder or other psychiatric disorders; 5. Alcohol or substance abusers; 6. Those who have taken antidepressants within 6 weeks (including 6 weeks); 7. Pregnancy or pregnancy preparation.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale, HAMA;Clinical Global Impression, CGI;Global Assessment Function,GAF;Pittsburgh sleep quality index, PSQI;self-rating depression scale, SDS;Ruminative Responses Scale, RRS;Athens Insomnia Scale, AIS;The World Health Organization Quality of Life (WHOQOL) -BREF;body movement record;10×Genomics Single-cell sequencing blood;Olink Histology Multifactor Assay;functional magnetic resonance imaging (fMRI); | — |
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale, HAMD-17; | — |
Countries
China
Contacts
Public ContactZhou Peng
Shenzhen Baoan District Hospital of Traditional Chinese Medicine
Outcome results
None listed