Gynecological uterine and adnexal diseases
Conditions
Interventions
Experimental group:Remazolam sedation
Sponsors
Mindong Hospital Affiliated to Fujian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing gynecological laparoscopic general anesthesia surgery (except for patients with malignant tumors); 2. Age 18-60 years; 3 Body mass index (BMI): 18.5-30 kg/m^2; 4 American Society of Anesthesiologists Grading (ASA) Grades I-III; 5. Subjects voluntarily participate in the trial and sign the informed consent form of the trial.
Exclusion criteria
Exclusion criteria: 1. The subject expressly refuses to participate in this study; 2. Those who are allergic to opioids, benzodiazepines, propofol, flumazenil or naloxone drug excipients; 3. Use of ß receptor blockers, anxiolytics, and antidepressants; 4. Those suspected of abusing narcotic analgesics or sedatives and alcoholics; 5. ECG indicates heart rate 100 times/min or severe arrhythmia; 6. History of acute respiratory infection with no cure within 2 weeks; 7. Those with a history of severe cardio-brain, lung, liver, kidney or metabolic diseases, neuromuscular system diseases (such as myasthenia gravis) and mental diseases; 8. Patients with preoperative hypertension have a systolic blood pressure > 180 mmHg and (or) diastolic blood pressure > 110 mmHg or 90/60 mmHg for hypotensive patients ; 9. Those who have a history of abnormal surgical anesthesia recovery; 10. Predictors of the possibility or occurrence of difficult airways, such as modified Markovian grades III-IV; 11. Pregnant or lactating women and patients with a birth plan within 3 months; 12. Other subjects considered inappropriate by other investigators to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of intraoperative hypotension; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vital signs;Anesthesia wake time;Adverse reactions; | — |
Countries
China
Contacts
Public ContactWeng Digui
Mindong Hospital Affiliated to Fujian Medical University
Outcome results
None listed