Postoperative cognitive dysfunction
Conditions
Interventions
Group R:Remimazolam for anesthesia induction and maintenance in group R
Group D:Dexmedetomidine for anesthesia induction and maintenance in group D
Group C:non-intervention
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged individuals (65-80 years old) receiving elective laparoscopic radical excision for gastric cancer; 2. American Society of Anesthesiologists (ASA) classification II-III; 3. BMI 18-24 kg/m^2; 4. To exclude bias due to different surgical practices and habits all patients were from the same group of surgeons.
Exclusion criteria
Exclusion criteria: 1. Preoperative Mini-mental State Examination(MMSE)or Montreal Cognitive Assessment(MoCA) cognitive dysfunction (preoperative scores <= 17 for illiterate, <= 20 for primary, <= 22 for secondary, and <= 23 for university); 2. History of cardiac surgery, cerebrovascular accident, and alcoholism; 3. Presence of serious organic diseases such as liver and kidney dysfunction; 4. Coagulation disorders; 5. Severe visual and hearing impairment that prevents communication; 6. History of psychiatric disorders or long-term sedation or depression medication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive function;Inflammatory factor;postoperative adverse reactions ; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood pressure and heart rate;Anesthesia Indicators; | — |
Countries
China
Contacts
Public ContactJia Min
The First Affiliated Hospital of Nanchang University
Outcome results
None listed