COVID-19
Conditions
Interventions
trial:taVNS
sham stimualtion:taVNS
Sponsors
Shanghai Yangzhi Rehabilitation Hospital(Shanghai sunshine Rehabilitation Center)
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. >= 65 years old; 2. COVID-19 with cough and respiratory involvementand the course of the disease is less than 2 months; 3. Oxygen saturation >93% without the need for mechanical ventilation or severe respiratory insufficiency that will require immediate intubation; 4. The patient has some cognitive ability and can do a simple cognitive assessment; 5. This study was approved by a medical ethics committee with the informed consent of patients or their families.
Exclusion criteria
Exclusion criteria: 1. Patients with severe cognitive impairment; 2. Already enrolled in a clinical trial for COVID-19; 3. History of aneurysm, intracranial hemorrhage, brain tumor, or significant head trauma; 4. Known or suspected severe atherosclerotic cardiovascular disease,severe carotid artery disease, congestive heart failure, known severe coronary artery disease, or recent myocardial infarction; 5. Uncontrolled high blood pressure; 6. Presence of an implanted electrical and/or neurostimulator device, metal cervical spine material, or a metal implant near the site of nVNS; 7. Currently taking medication to improve her cognitive function.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IL-6;C-reactive protein, CRP; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination, MMSE;Heart rate variablity, HRV;Self-Rating Depression Scale, SDS;S100ß; | — |
Countries
China
Contacts
Public ContactBin Yu
Shanghai Yangzhi Rehabilitation Hospital(Shanghai sunshine Rehabilitation Center)
Outcome results
None listed