Observation on rehabilitation effects of transcuta neous auricular vagus never stimulation on patients with chronic ischemic stroke

Observation on rehabilitation effects of transcutaneous auricular vagus never stimulation on patients with chronic ischemic stroke

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300068033

Enrollment

Unknown

Registered

2023-02-03

Start date

2023-02-01

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic ischemic stroke

Interventions

Combination of vagus nerve and rehabilitation 1 group:30Hz taVNS

Combination of vagus nerve and rehabilitation 2 groups:300Hz taVNS

Combination of vagus nerve and rehabilitation 3 groups:3000Hz taVNS

Control group:sham stimulation

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. It meets the diagnostic criteria of stroke in the diagnostic points of various cerebrovascular diseases and is confirmed by brain CT or MRI examination; 2. Patients with the first onset and the course of disease within 9 months are stable after acute treatment; 3. Upper limb motor dysfunction; 4. The cognitive function of patients is clear and they have the ability to give informed consent and understand instructions; 5. The study was approved by the Medical Ethics Committee and the informed consent of the patients or their families.

Exclusion criteria

Exclusion criteria: 1. Hemorrhagic stroke; 2. Surgical intervention has been performed on the vagus nerve in the past; 3. Sinus bradycardia (HR < 60 bpm); 4. Cognitive impairment or any significant decline in alternate language reception or attention may affect the understanding of motor test instructions; 5. Limb apraxia; 6. Excessive pain in any joint of paralyzed limb; 7. Advanced liver, kidney, heart, or lung diseases; 8. History of serious alcoholism or drug abuse; 9. Depression or use of neuropsychiatric drugs such as antidepressants or benzodiazepines; 10. Botulinum toxin injection or any other non-research active upper limb rehabilitation 12 weeks before or during treatment; 11. Pregnancy.

Design outcomes

Primary

Measure	Time frame
Fugl-Meyer, FMA;	—

Secondary

Measure	Time frame
Modified Barthel Index, MBI;Modified Ashworth Scale, MAS;Hamilton Depression Scale, HAMD;	—

Countries

China

Contacts

Public ContactBin Yu

Shanghai Yangzhi Rehabilitation Hospital(Shanghai sunshine Rehabilitation Center)

yubin@tongji.edu.cn+86 139 1810 8880

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026