malignant pleural effusion
Conditions
Interventions
Gold Standard:Pleural effusion or pleural biopsy histopathology revealed malignant cells.
Index test:MPE diagnosis model based on MPE specific protein detection combined with machine learning based on clinical data.
Sponsors
Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University.
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for MPE patients were as follows: 1. Positive cytology of pleural effusion; 2. Tumor cells were detected in pleural biopsy tissue; Inclusion of patients with benign pleural effusion: 1. Tuberculous pleuritis: granuloma was detected in pleural biopsy tissue, and acid-fast staining was positive; Acid fast staining or nucleation culture of pleural effusion was positive. 2. Cardiogenic pleural effusion: The patient had a history of heart failure, heart failure confirmed by color doppler echocardiography, increased BNP, and sensitive to diuretic treatment; 3. Parapneumonic pleural effusion: the patient was clearly diagnosed with pneumonia and was sensitive to antibiotic treatment; 4. Others: pleural effusion caused by nephrotic syndrome, cirrhosis, hypoproteinemia, etc.
Exclusion criteria
Exclusion criteria: Patients with critical illness; Patients younger than 18 years old.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| area under the curve;sensitivity;specificity; | — |
Countries
China
Contacts
Public ContactYongchun Shen
Outcome results
None listed