hepatitis B
Conditions
Interventions
Immune tolerance period antiviral group:None
Immune tolerance period without antiviral group:None
GP73 normal group:None
Abnormal GP73 group:None
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
15 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. HBV DNA>= 1.00E+07 IU/ML; 2. Serum HBsAg positive for at least 6 months and HBeAg positive; 3. Serum ALT was normal or < 2 x ULN; 4. No liver cirrhosis was indicated by Fibroscan < 9.0kpa and liver color ultrasound within the last 3 months, or no obvious inflammatory necrosis or fibrosis was observed by liver histopathological examination within the last 1 year; 5. All patients can be treated initially or after treatment.
Exclusion criteria
Exclusion criteria: 1. Cirrhosis, tumor, connective tissue disease, etc.; 2. Exclude alcoholic liver, drug hepatitis, autoimmune hepatitis, hepatitis A vale, etc.; 3. Serious dysfunction of heart, lung, liver, kidney and other systems; 4. Subjects with serious mental illness, pregnancy or lactation; 5. Conditions that other researchers consider unsuitable for participating in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HBVDNA quantification; | — |
Secondary
| Measure | Time frame |
|---|---|
| GP73;HBsAg quantification;HBeAg quantification;ALT quantification; | — |
Countries
China
Contacts
Public ContactXueZhong Lei
West China Hospital of Sichuan University
Outcome results
None listed