Endothelial progenitor cell senescence induced by intermittent hypoxia via Smad3/PAPD5 axis in the genesis of atherosclerotic diseases

Status

Recruiting

Phases

Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2300067991

Enrollment

Unknown

Registered

2023-02-02

Start date

2023-02-03

Completion date

Unknown

Last updated

2023-08-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive sleep apnea, coronary atherosclerotic disease, and angina pectoris, senescence

Interventions

Angina patients undergoing PCI:none

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Medical resources and labor are available at time 2. vital signs are stable and sleep test can be completed 3. non-acute myocardial infarction patients completed PCI on LM and LAD.

Exclusion criteria

Exclusion criteria: 1. unstable angina even after PCI 2. difficulties in falling asleep due to varying causes 3. advanced tumor, heart failure, and COPD with limited life expectancy 4. significant mental-neurological abnormalities 5. infection state 6. previous OSA diagnosis and present CPAP treatment 7. diabetic mellitus 8. current smoker 9. oxygen supplementation during night time

Design outcomes

Primary

Measure	Time frame
Senescence of the endothelial progenitor cells;MACE;patency of coronary artery;Arterial function;	—

Countries

China

Contacts

Public ContactJiang Xie

Beijing Anzhen Hospital, Capital Medical University

frank782008@aliyun.com+86 131 6198 5564

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 7, 2026