Parkinson
Conditions
Interventions
Experimental Group:Transcutaneous ear vagus nerve stimulation
Control Group:sham Transcutaneous ear vagus nerve stimulation
Sponsors
Zhejiang Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria of the Chinese Parkinson's disease diagnostic criteria (2016 edition); 2. Parkinson's stage is greater than or equal to stage 2 to stage 5; 3. Disease duration >=5 years; 4. Volunteer to participate in this study and sign the research informed consent.
Exclusion criteria
Exclusion criteria: 1. People with metal implants in the body, such as those with a pacemaker in the heart; 2. People with severe disturbance of consciousness or unable to cooperate with follow-up treatment evaluation; 3. People with a history of epilepsy in the past, or people with epilepsy after the onset; 4. People with severe heart disease. , liver, kidney and other organ dysfunction; 5. progressive disease and significantly increased intracranial pressure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NMSS, non-motor symptom scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| UPDRS, unified Parkinson’s Disease rating scale;MMSE, Minimal Mental State Examination;QOL,Quality of Living; | — |
Countries
China
Contacts
Public ContactZhenhua Jin
Zhejiang Provincial People's Hospital
Outcome results
None listed