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The Mechanism Study of Electronic Moxibustion Intervening Pain Transformation of Herpes Zoster by TRPV1 Regulating S100A8/9

The Mechanism Study of Thermal-sensitive Electric Moxibustion Intervenes Pain Transformation of Herpes Zoster by Regulating S100A8/A9 through TRPV1

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300067986
Enrollment
Unknown
Registered
2023-02-02
Start date
2023-02-02
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

herpes zoster

Interventions

experimental group:medicine+moxbustion

Sponsors

The First People's Hospital of Changde City
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Signed the informed consent form and was willing to participate in the study; 2. For those aged 50 years and above, gender is not limited; 3. HZ was diagnosed in thoracic segment (T2 - 10); 4. The eruption occurred within 1~7 days; 5. Baseline pain intensity 11-point NRS score = 4 points (baseline pain intensity is the average pain intensity score within 24 hours before randomization); 6. Patients without antiviral and analgesic treatment

Exclusion criteria

Exclusion criteria: 1. HZ in other parts than thoracic segment; 2. Patients with severe diabetes mellitus, malignant tumor, severe cardiovascular and cerebrovascular diseases, liver, kidney, hematopoietic system and other primary diseases or systemic failure, mental patients, hemophilia patients, patients with bleeding tendency and local skin lesions ulceration and infection; 3. Pregnant or lactating women; 4. The patient is in critical condition, and it is difficult to make exact evaluation on the effectiveness and safety of treatment.

Design outcomes

Primary

MeasureTime frame
pain grade;Incidence of PHN;

Secondary

MeasureTime frame
Skin lesion recovery;Quality of life assessment;Peripheral blood inflammatory mediators;Transcriptomics of Peripheral Blood Mononuclear Cells;

Countries

China

Contacts

Public ContactSUN Wen-qin

The First People's Hospital of Changde City

15873666967@163.com+86 158 7366 6967

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026