vitiligo
Conditions
Interventions
Group1 conventional therapy group :topical ruxolitinib cream
Group2 positive therapy group :topical exosomes gel
Group3 Control group :topical negative gel
Sponsors
Third hospital of Hangzhou
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. >= 18 years old and <= 65 years old, regardless of gender. 2. According to the consensus on the diagnosis and treatment of vitiligo, the researcher evaluated that the subject is suitable for local treatment of vitiligo. 3. There are more than 3 target lesions near the observation site or symmetrical site, and the diameter of each skin lesion photographed is at least 2-3cm. 4. The screening period and pre-randomization pregnancy test of women with fertility potential must be negative. 5. Fully understand the test content, voluntarily participate in the test, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Segmental vitiligo, acrosomal vitiligo or mucosal vitiligo. 2. Within 4 weeks before the test, the patient is receiving systematic treatment (such as oral glucocorticoid or JAK inhibitor or other immunosuppressants), or the target skin lesion is being treated with glucocorticoid, calcineurin inhibitor, PDE-4 inhibitor, etc. 3. Currently, phototherapy is used. 4. Suffering from active autoimmune diseases (such as atopic dermatitis, alopecia areata, thyroid disease), infectious diseases such as hepatitis B and hepatitis C, cerebrovascular diseases, serious ECG abnormalities, severe or progressive or uncontrolled kidney, liver, blood, digestion, metabolism, endocrine, lung, cardiovascular or nervous system diseases; Or the laboratory test value during screening has clinical significance, and the researcher judges that it is not suitable to participate in the study. 5. The following vulnerable groups will not be included in the study: including the mentally ill, critically ill, pregnant women, illiterate, minors, cognitive impairment, students of PI or researchers, subordinates of PI or cooperative researchers, employees of research units or sponsors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| skin computed tomography;Vitiligo Area Scoring Index;initiation of effect; | — |
Secondary
| Measure | Time frame |
|---|---|
| pattern of repigmentation;Skin area scanning; | — |
Countries
China
Contacts
Public ContactAi-e Xu
Third Hospital of Hangzhou
Outcome results
None listed