Psoriasis
Conditions
Interventions
1 conventional therapy group:topical Calcipotriol cream
2 positive therapy group:topical exosomes gel
Control group:topical negative gel
Sponsors
Third hospital of Hangzhou
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. >= 18 years old and <= 65 years old, regardless of gender. 2. Mild to moderate psoriasis vulgaris diagnosed according to the Chinese Guidelines for the Diagnosis and Treatment of Psoriasis (PASI score<10), and those who do not need systematic treatment at present, are suitable for local treatment of psoriasis. 3. There are more than 3 target lesions in the adjacent or symmetrical parts, and the diameter of each lesion should be at least 3cm. 4. The screening period and pre randomization pregnancy test of women with fertility potential must be negative. 5. Fully understand the test content, voluntarily participate in the test, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 2. They were receiving biological agents, traditional therapeutic drugs (acitretin, methotrexate, cyclosporine) and immunosuppressants within 4 weeks before the test; The target skin lesions are treated with topical hormones or calcineurin inhibitors or vitamin D3 derivatives, PDE-4 inhibitors and other drugs. 3. Currently, phototherapy is used. 4. Active autoimmune disease (inflammatory bowel disease), hypertension, cardiovascular disease, obesity, metabolic syndrome, arthritis, psychosomatic disorder, skin tumor, smoking, alcoholism, oral mucosa and temporomandibular joint, periodontitis, obstructive sleep apnea, chronic obstructive pulmonary disease, osteoporosis, Parkinson's disease, celiac erectile dysfunction, serious infection and other common diseases; Severe or progressive or uncontrolled kidney, liver, blood, digestive, endocrine or nervous system diseases or laboratory test values during screening have clinical significance, and the researcher judged that it is not suitable to participate in the study. 5. The following vulnerable groups will not be included in the study: including the mentally ill, critically ill, pregnant women, illiterate, minors, cognitive impairment, students of PI or researchers, subordinates of PI or cooperative researchers, employees of research units or sponsors
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Psoriasis Area and Severity Index;initiation of effect; | — |
Secondary
| Measure | Time frame |
|---|---|
| degree of epidermal infiltration;Numbers of erythema and scales; | — |
Countries
China
Contacts
Public ContactAi-e Xu
Third Hospital of Hangzhou
Outcome results
None listed