COVID-19
Conditions
Interventions
experimental group:Standard treatment+Colchicine
control group:Standard treatment
Sponsors
Lanzhou University Second Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Age= 18 years old; (2) Inpatient treatment in the Second Hospital of Lanzhou University; (3) Positive COVID-19 nucleic acid test within 24 hours; (4) Combined with = 2 of the following clinical manifestations:?fever (body temperature >37.3 °C);? persistent cough;?persistent dry throat and sore throat;?muscle soreness;?loss or loss of smell and/or taste;?General symptoms of viral influenza such as nasal congestion, runny nose, headache, fatigue, etc.;?Increased breathing (respiratory rate> 25 times/min;? Reduced blood oxygen saturation (<95%)? (5) Chest CT showed viral pneumonia. (6) Female patients are not fertile (at least 1 year after menopause or sterilization) or fertile but use effective contraceptive methods. (7) Voluntary signing of informed consent: Patients and their families voluntarily sign the informed consent form after the investigator informs the investigator of the study-related matters in person, indicating that they voluntarily participate in the study and can comply with the requirements of the study follow-up plan and other protocols.
Exclusion criteria
Exclusion criteria: (1) Pregnant and lactating women. (2) Those who are allergic to constitution or multiple drugs (3) Those with a history of liver cirrhosis, chronic active hepatitis, severe liver disease or severe liver insufficiency (Child-Pugh grade C). (4) Severe renal insufficiency (estimated GFR 450 milliseconds. (7) Those with low bone marrow hyperplasia. (8) Those with colchicine and other indications (such as: gout, familial Mediterranean fever) are being treated. (9) Those who are participating in other clinical trials. (10) Those who refuse to accept the study or cannot cooperate for any reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of ILD;Warrick score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Lung function parameters;arterial partial pressure of oxygen;Warrick score of chest CT;SF-36 score;Murray lung injury score;adverse event; | — |
Countries
China
Contacts
Public ContactZhang Sigong
Lanzhou University Second Hospital
Outcome results
None listed