Orthopedic related diseases
Conditions
Interventions
Group A:Before skin incision, tranexamic acid was intravenously infused. After operation, tranexamic acid was used at the same time point in group B, and gum was not chewed after operation.
Group B:Tranexamic acid was infused intravenously before skin incision. Tranexamic acid was used at different time points after operation, and chewing gum at different time points was selected.
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: The diagnosis of our hospital is: 1.lumbar degenerative disease; 2.cervical degenerative disease; 3.Thoracic degenerative diseases; 4.Adolescent idiopathic scoliosis; 5.Spinal kyphosis; 6.Spinal tumors; 7.Spinal fractures; 8.Spinal tuberculosis; 9.Degenerative hip disease; 10.Patients with orthopedic-related diseases such as knee degenerative diseases and requiring orthopedic-related surgery; Voluntarily join this study and sign the informed consent form; Preoperative hemoglobin (Hb) and coagulation function were normal; no abnormal lower extremity venous ultrasound
Exclusion criteria
Exclusion criteria: 1. Preoperative anemia (Hb: female III; 8. Patients with history of any psychiatric illness; 9. Patients who have undergone lumbar surgery in the past; 10. Patients combined with lumbar tumour, tuberculosis, infection or lumbar vertebral fracture caused by trauma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Basic demographic parameters ( age, gender, height, weight, etc.);Gastrointestinal function indicators (first defecation, exhaust, bowel sound recovery time, constipation, abdominal distension, nausea, vomiting,oral comfort, etc.);Liver and kidney function (prealbumin, total protein, Alb, ALT, AST, BUN, Cr ,etc.);Inflammatory response related indicators;Length of stay ( total length of stay, preoperative length of stay, postoperative length of stay, etc.);Drainage tube removal time, postoperative bed rest time to ambulation time, etc.;Postoperative complication(exudation, hematoma, infection, etc.);Medical expenses;Duration of operation (min), length of incision (cm);Postoperative wound drainage volume, HCT of postoperative wound drainage fluid;Pain-related parameter indicators;Anesthesia related parameters ( ASA classification, cardiopulmonary function classification, Mallampati classification, etc.);Clinical diagnosis, past history, osteoporosis, etc.;Chalybeate, EPO, anti-inflammatory and analgesic drugs and other drugs use and follow-up.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood loss related parameters (total blood loss,postoperative blood loss, dominant blood loss, hidden blood loss, intraoperative blood loss, drainage fluid blood content, etc.);Bood routine(HCT?Hb?RBC;PLT);Coagulation and fibrinolysis indexes(PT?INR?APTT?TT?FIB?FDP?D-D);Coagulation factors(???????????????);Thrombelastogram(TEG);The incidence of thrombosis ( deep vein thrombosis, muscular calf vein thrombosis, pulmonary embolism, myocardial infarction, etc.); | — |
Countries
China
Contacts
Public ContactZhenming Hu
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed