Postoperative cognitive dysfunction
Conditions
Interventions
Sponsors
The Second Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 65-80 years; 2. ASA grade II-IV; 3. Patients receiving coronary artery bypass surgery under elective general anesthesia; 4. Agree and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Pre-existing psychological and/or mental illness; 2. Suffering from Parkinson's disease; History of epilepsy; 3. Previous history of craniocerebral surgery; 4. Cerebrovascular diseases; 5. Severe hepatic insufficiency, acute kidney injury or renal insufficiency (eGFR < 30 ml/min/1.73m2); 6. Hearing impairment, vision or speech impairment, which prevents communication; 7. Conditions that are not suitable for MRI examination (such as claustrophobia); 8. Patients with contraindications of gadolinium contrast agent; 9. Reluctance to complete repeated MRI and neuropsychological tests (NPT).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ktrans values;Postoperative cognitive dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative delirium;inflammatory factor;perioperative covert stroke;Matrix metallopeptidase 9;brain microvascular endothelial cells;S100 beta protein; | — |
Countries
China
Contacts
Public ContactLining Huang
The Second Hospital of Hebei Medical University
Outcome results
None listed