Effect and mechanism of sodium bicarbonate Ringer solution in anesthesia of adult cardiopulmonary bypass cardiac surgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300067798

Enrollment

Unknown

Registered

2023-01-28

Start date

2023-02-01

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac surgery under cardiopulmonary bypass

Interventions

group 1:Ringer solution of sodium bicarbonate

group 2:Lactate Ringer's solution

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. >= 18 years old; 2. Gender is not limited; 3. Open heart surgery under cardiopulmonary bypass, including valve replacement and atrial myxoma surgery; 4. Blood potassium, blood magnesium, blood sodium, PH value and HCO3 - concentration were normal before operation; 5. Renal function is normal.

Exclusion criteria

Exclusion criteria: 1. Deep hypothermic cardiopulmonary bypass; 2. Re-operation due to bleeding or other reasons after operation.

Design outcomes

Primary

Measure	Time frame
Endothelial cell glycocalyx metabolite;	—

Secondary

Measure	Time frame
TNF-a;Serum creatinine and blood urea nitrogen;Blood gas analysis results;	—

Countries

China

Contacts

Public ContactZhang Min

Department of Anaesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China

syzhangmin@ustc.edu.cn+86 138 6671 6646

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026