glioma
Conditions
Interventions
Sponsors
Zhujiang Hospital, Southern Medical University, Guangzhou
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for Disease Group: 1. The patients were diagnosed with glioma by pathological diagnosis after the first surgical treatment; 2. The patients had no history of radiotherapy or chemotherapy before the operation; 3. The patient had complete and necessary clinical information or laboratory data; 4. The patients had no history of inflammatory bowel disease, acute or chronic gastrointestinal disease; 5. The patients were not associated with other severe physical and mental disorders; 6. The patients or his/her guardian/legal representative voluntarily participated with the study and subscribed the Informed Consent Form. Inclusion criteria for Healthy Control: 1. All participants were matched for age, sex, and body mass index (BMI) to the disease group; 2. All participants blood, stool and urine laboratory data were normal, and the brain computerized tomography did not find primary and metastatic tumor in brain; 3. All participants had no history of inflammatory bowel disease, acute or chronic gastrointestinal disease; 4. All participants were not associated with other severe physical and mental disorders; 5. All participants or his/her guardian/legal representative voluntarily participated with the study and subscribed the Informed Consent Form.
Exclusion criteria
Exclusion criteria: 1. All participants were not undergoing antibiotics and probiotics treatment within 2 months before the biological specimens were collected; and known active bacterial, fungal, or viral infections; 2. All participants were found severe systemic diseases in this time health check: hypertension (diastolic pressure >= 100 mmHg or systolic pressure >= 160 mmHg), cardiovascular disease, diabetes mellitus, rheumatic disease, active period of acute and chronic infectious diseases; 3. All participants were in pregnancy and lactation; 4. The subjects had a history of malignant tumors; 5. All participants had a previous history of gastrointestinal surgery and had intestinal invasive examinations within 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diversity and difference of intestinal microbiota in all participants;Diversity and difference of intratumoral microbiota in all participants; | — |
Countries
China
Contacts
Public ContactSun Haitao
Zhujiang Hospital, Southern Medical University
Outcome results
None listed