Port wine stains
Conditions
Interventions
Fundamental single HMME-PDT group:HMME-PDT
Advanced rapamycin RPM-HMME-EPDT sensitization group :RPM-HMME-EPDT sensitization therapy
Premium PT-HMME-APDT ablation group :PT-HMME-APDT ablation
Sponsors
Shanghai Skin Disease Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years old; 2. Clinically diagnosed as port wine stains (PWS); 3. According to the routine judgment of clinical diagnosis and treatment, the dermatologist should give heimpofen for injection; 4. The patient signed an informed consent and agreed to receive regular therapeutic follow-up.
Exclusion criteria
Exclusion criteria: 1. People with allergic diseases, Including with light skin allergies disease, porphyria patients or known allergic to test drugs and its chemical structure similar drugs, such as blood porphyrin, light porphyrin, lindsey, sodium, for mooring Finn, mo luo tabor Finn, methylene blue and toluidine blue, d for mooring Finn, phthalocyanine, Texas porphyrin, mooring Finn, st John's wort element and terah in biosynthesis in vivo porphyrin and ammonia ketone pentanoic acid hydrochloric acid, etc); 2. Allergic or scar diathesis people; 3. Pregnant patients or those who are unwilling to take effective contraceptive measures during the treatment period (within 1 month after the use of hematoporphyrin for injection); 4. Others deemed unsuitable for the study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PWS optical grading; | — |
Secondary
| Measure | Time frame |
|---|---|
| general information assessment;lesion photograph;laboratory tests: blood routine, urine routine, liver function, kidney function, electrocardiogram (12 leads);non-invasive examinations: Visia skin analyzer photography; Dermoscopy photography; photoacoustic /RCM bimodal imaging;histopathology biopsy; | — |
Countries
China
Contacts
Public ContactPeiru Wang
Shanghai Skin Disease Hospital
Outcome results
None listed