Hypercholesterolemia
Conditions
Interventions
Intervention group:Protocatechuic acid capsules for three months, one capsule per day
Control group:Placebo capsules for three months, one capsule per day
Sponsors
Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
35 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age between 35-65 years old, BMI: 24-30kg/m^2, permanent resident of Guangzhou City (those who have lived in Guangzhou for more than 10 years); 2. The concentration of total cholesterol in fasting blood was between 200-310 mg/dL (5.2-8.0 mmol/L); 3. The smoking index is less than 400 years (smoking index = number of cigarettes smoked per day x smoking years); 4. Weekly alcohol consumption is less than 175g of alcohol; 5. The cumulative time of weekly high-intensity exercise does not exceed 75 minutes or the cumulative time of moderate-intensity exercise does not exceed 150 minutes; 6. Voluntarily participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Have a serious chronic disease that may affect this trial, such as tumors, chronic heart failure, severe depression or other mental disorders, physical disabilities or inability to move freely; 2. Currently taking or having taken any drugs that affect blood lipids and blood sugar in the past six months; 3. Patients with poor compliance; 4. Have suffered from acute and chronic infectious diseases, autoimmune diseases, malignant tumors, trauma or surgery within one month before the test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Flow-mediated dilation function measured by color Doppler ultrasonography; | — |
Secondary
| Measure | Time frame |
|---|---|
| Height;Weight;Waist circumference;Hip circumference;Body fat percentage;Blood pressure;Heart rate;Blood lipids (total cholesterol, triglycerides, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol);Kidney function (creatinine, uric acid, urea nitrogen);Liver function (glutamic-pyruvic transaminase, glutamic oxalacetic transaminase);Blood glucose;Insulin;Bilirubin;Hemoglobin;HDL anti-atherosclerotic function (antioxidant and cholesterol efflux);Serum cytokines adiponectin, leptin, TNF-a, IL-1ß and IL-6;Serum superoxide dismutase;Serum glutathione peroxidase;Malondialdehyde content;Protocatechuic acid content in blood, urine and stool; | — |
Countries
China
Contacts
Public ContactDongliang Wang
Sun Yat-sen University
Outcome results
None listed