Ear, nose and throat disease
Conditions
Interventions
P group:Intravenous induction of propofol 2kg/mg, Anesthesia maintenance: propofol 4mg/kg/h, remifentanil 0.2 µg/kg/min
R group:Intravenous induction of remazolam 0.3kg/mg, Anesthesia maintenance: remazolam 1mg/kg/h, remifentanil 0.2µg/kg/min
Sponsors
The Third People's Hospital of Hubei Province
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years; 2. ASA I-II; 3. Who were scheduled for elective short otorhinolaryngologic surgery; 4. Support laryngoscopic surgery (support laryngoscopic excision of epiglottic cyst, support laryngoscopic excision of glottic polyp), endoscopic septoplasty, endoscopic tympanoplasty, and endoscopic middle ear catheterization were planned, and the operation time was not more than 90 minutes.
Exclusion criteria
Exclusion criteria: 1. The patient had severe heart, brain, kidney, lung and liver diseases and refractory hypertension; 2. Severe bradycardia, heart rate < 50 times/min; 3. Suffering from mental illness and long-term use of psychotropic drugs; 4. Cognitive dysfunction; 5. Allergic or contraindicated to the components of benzodiazepines; 6. Used other sedatives in the last week.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sedation agitation score;Spontaneous breathing recovery time;Waking time;Extubation time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic changes ;Adverse reaction indicators: postoperative hypotension, hypoxemia, bradycardia, dizziness, lethargy, nausea and vomiting; | — |
Countries
China
Contacts
Public ContactYu Di
The Third People's Hospital of Hubei Province
Outcome results
None listed