Effect of Electroacupuncture with Different Parameters on Patients with Alzheimer's disease: A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300067721

Enrollment

Unknown

Registered

2023-01-19

Start date

2023-01-20

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer's disease

Interventions

Electroacupuncture 2Hz:Waveform: continuous wave

Frequency: 2Hz

Current intensity: 0.5-5.0mA, tolerated by patients

time: 20min.

Electroacupuncture 100Hz:Waveform: continuous wave

Frequency: 100Hz

time: 20min

Electroacupuncture 2/100Hz:Waveform: dense wave, frequency: 2Hz/100Hz, current intensity: 0.5-5.0mA, depending on patient tolerance.

Eligibility

Sex/Gender

All

Age

50 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Meet the DSM-IV-R dementia diagnostic criteria; 2. Comply with the NIA-AA standard in the most likely AD standard; 3. Aged 50-85 years; 4. Clinical Dementia Rating >= 0.5, MMSE <= 26; 5. Hachinski Ischemia Scale score <= 4; 6. Sign the informed consent form and voluntarily participate in this trial.

Exclusion criteria

Exclusion criteria: 1. Accompanied by severe cerebrovascular diseases; 2. Accompanied by other diseases that can cause cognitive dysfunction or progressive memory impairment; 3. Drug-induced cognitive dysfunction or progressive memory impairment; 4. Patients with severe needle fear, needle sickness, and severe skin infection; 5. Patients with severe cardiovascular diseases, malignant tumors, severe liver and kidney insufficiency; 6. Patients who are highly dependent on nursing facilities; 7. Have received acupuncture treatment within the past 2 weeks; 8. Currently participating in other clinical trials; 9. Patients who refuse to sign informed consent.

Design outcomes

Primary

Measure	Time frame
Alzheimer's disease assessment scale cognition, ADAS-Cog;	—

Secondary

Measure	Time frame
Activity of daily living scale, ADL;Neuropsychiatric inventory;Clinician's interview-based impression of change, CIBIC;Pittsburgh Sleep Quality Index, PSQI;Zarit Caregiver Burden Interview, ZBI;Acupuncture Expectation Scale, AES;Treatment Satisfaction Survey, TSS;	—

Countries

China

Contacts

Public ContactJia Baohui

Guang'anmen Hospital, China Academy of Chinese Medical Sciences

myrroossee@aliyun.com13520090050

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026