pneumocystis jirovecii pneumonia
Conditions
Interventions
Gold Standard:Real-time qPCR and IF staining tests were performed on BAL fluid samples to detect P. Jirovecii. QPCR >0 pathogens/mL was considered as qPCR (+). IF staining was considered positive when
Index test:A clinical-imaging model constructed by clinical and semantic CT features as independent factors selected by univariate analysis and multivariate logistic regression
A radiomic model consisting of radiomic features selected by Student's t-test, Mann-Whitney U-test and LASSO and constructed by logistic regression, support vector
Sponsors
Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged over eighteen years; 2. Presence of an underlying disease known to be associated with PCP; 3. Symptoms of lower respiratory tract infection, such as fever, cough or dyspnea; 4. Signs of lung infection on high resolution CT at the on-set of the disease; 5. Received BAL examination within three days after CT scans; 6. Underwent qPCR and IF staining tests on the BAL fluid sample.
Exclusion criteria
Exclusion criteria: 1. Patients with HIV infection; 2. Those taking trimethoprim-sulfamethoxazole for prophylaxis; 3. Those undiagnosed by qPCR and IF staining tests.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Radiomic model;sensitivity;Specificity;Accuracy;Positive predictive value;Negative predictive value; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical-imaging model; | — |
Countries
China
Contacts
Public ContactLiang'an Chen
Chinese PLA General Hospital
Outcome results
None listed