AIM2 forms a PANoptosome complex with ZBP1 induced by mtDNA to drive sepsis-induced cardiomyopathy

AIM2 forms a PANoptosome complex with ZBP1 induced by mtDNA to drive sepsis-induced cardiomyopathy - AIM2 forms a PANoptosome complex with ZBP1 induced by mtDNA to drive sepsis-induced cardiomyopathy

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2300067689

Enrollment

Unknown

Registered

2023-01-18

Start date

2023-01-18

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sepsis-induced cardiomyopathy

Interventions

sepsis group:nonintervention

sepsis-induced cardiomyopathy group:nonintervention

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Age >18 and < 80 years old; (2) Satisfy the two following conditions: ? Satisfy the diagnostic criteria of sepsis 3.0; ? Echocardiography was performed within 24 hours after admission; (3) Informed consent was signed.

Exclusion criteria

Exclusion criteria: (1) Hemodynamically unstable patients with systolic blood pressure (SBP) 15µg/kg/min, norepinephrine >15µg/ min); (2) Estimate patients probably to die within 24 hours after admission to ICU; (3) History of cardiac valves; (4) Patients with chronic heart failure (CHF) with coronary artery disease (CAD) and hypertrophic Cardiomyopathy (HCM) or other history of ischemic heart disease; (5) Patients with atrial fibrillation; (6) Pregnant women; (7) Unclear ultrasound images or incomplete clinical data; (8) Refuse to participate in the study;

Design outcomes

Primary

Measure	Time frame
plasma mtDNA copy number;	—

Countries

China

Contacts

Public ContactFengmei Guo

Zhongda Hospital, School of Medicine, Southeast University

13813841261@139.com+86 138 1384 1261

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026