Effect of target-controlled infusion of remifentanil combined with propofol at different plasma concentrations under monitored anesthesia care (MAC) during vitrectomy

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300067681

Enrollment

Unknown

Registered

2023-01-17

Start date

2023-02-01

Completion date

Unknown

Last updated

2024-09-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

anesthesia

Interventions

A group :intravenous TCI remifentanil was initially measured as 0.4ng/ml

B group:intravenous TCI remifentanil was initially measured as 0.5ng/ml

C group:intravenous TCI remifentanil was initially measured as 0.6ng/ml

Eligibility

Sex/Gender

All

Age

45 Years to 59 Years

Inclusion criteria

Inclusion criteria: Patients who 1. undergo Vitrectomy under monitored anesthesia care(MAC); 2. were 45-59 year old; 3. meet the classification I-II of American Society of Anesthesiologists (ASA); 4. NYHA grade I-II; 5.18.5 <= BMI < 28 kg/m2 and 6. given written informed consent were selected.

Exclusion criteria

Exclusion criteria: Patients weith the following medical history criteria will be excluded from the study: 1. Mental illness; 2. severe respiratory disease; 3. severe cardiovascular system disease; 4. history of drug addiction; 5. history of motion sickness ; 6. history of postoperative nausea and vomiting; 7. speech and hearing impairment.

Design outcomes

Primary

Measure	Time frame
Incidence of SpO2 lower than 90%;	—

Secondary

Measure	Time frame
incidence of unanticipated somatokinetic response;partial pressure of CO2 at the end of nasal breath;incidence of oculocardiac reflex;incidence of postoperative nausea and vomiting;total operative bipropofol and plasma bar concentration;operation time;the incidence of oral analgesics within 24 h after operation;verbal rating scale (VRS) score 24 h after operation;satisfaction scores of patients upon discharge;	—

Measure

Time frame

incidence of unanticipated somatokinetic response;partial pressure of CO2 at the end of nasal breath;incidence of oculocardiac reflex;incidence of postoperative nausea and vomiting;total operative bipropofol and plasma bar concentration;operation time;the incidence of oral analgesics within 24 h after operation;verbal rating scale (VRS) score 24 h after operation;satisfaction scores of patients upon discharge;

—

Countries

China

Contacts

Public ContactSun Ruiqiang

Tianjin Eye Hospital

673993820@qq.com+86 186 0264 3440

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026