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Study on Mechanism of Guipi Decoction in Treating Elderly Depression with Deficiency of Heart and Spleen Based on Cortical Plasticity

Study on Mechanism of Guipi Decoction in Treating Elderly Depression with Deficiency of Heart and Spleen Based on Cortical Plasticity

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300067668
Enrollment
Unknown
Registered
2023-01-17
Start date
2023-01-31
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

depression

Interventions

Guipi Decoction Group :Taking Guipi Decoction
Western Medicine Group :Taking escitalopram oxalate tablets

Sponsors

The Second People's Hospital of Lishui
Lead Sponsor

Eligibility

Sex/Gender
Male

Inclusion criteria

Inclusion criteria: Guipi Decoction Group and Western Medicine Group 1.It meets the diagnostic criteria of Chinese and Western medicine for depression, and the syndrome is of the heart and spleen deficiency type; 2.Age is greater than or equal to 60 years old; 3.The HAMD-17 score is greater than or equal to 17 points; 4.There is no contraindication to transcranial magnetic stimulation; 5.The subject or the legal guardian signed the informed consent form. Healthy control group 1. Comply with the provisions of the Chinese Standard for the Healthy Elderly (2013); 2. Age >= 60; 3. No contraindication of transcranial magnetic stimulation; 4. The subject or legal guardian signs the informed consent form.

Exclusion criteria

Exclusion criteria: 1.Combined with severe cognitive impairment or other mental disorders, unable to cooperate with treatment; 2.Combined with severe failure of important organs such as heart, liver and kidney; 3.Serious suicidal tendency; 4.Have a history of taking antipsychotics in the past 2 weeks, and use long-acting antipsychotics in the past 1 month; 5.Participate in other related clinical researchers.

Design outcomes

Primary

MeasureTime frame
Hamilton Depression Scale;Montgomery-Asberg Depression Rating Scale;Cortical plasticity;

Secondary

MeasureTime frame
Activities of Daily Living Scale; Assessing Health State Utility Using the Short Form36 ;

Countries

china

Contacts

Public ContactKunqiang Yu

Lishui Second People's Hospital

shiweiykq@163.com+86 181 5787 6936

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026