Parkinson's disease
Conditions
Interventions
1:In the first stage, Tai Chi based AOT combined with rTMS at DLPFC was performed
after the washout period, the second stage of Tai chi based AOT combined with sham rTMS was performed
2:In the first stage, Tai Chi based AOT combined with sham rTMS was performed
after the washout period, the second stage of Tai Chi based AOT combined with rTMS at DLPFC was performed
Sponsors
Academy of medical engineering and translational medicine
Eligibility
Sex/Gender
All
Age
55 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. aged 55 to 75 years; 2. idiopathic PD patients diagnosed according to the UK Brain Bank criteria; 3. Hoehn and Yahr (H&Y) stage 1 to 2.5 while ON medication; 4. treatment with anti-Parkinson's disease medication and stable dose for the past 1 month; 4. ability to walk independently; 5. adequate hearing and vision; 6. volunteered to participate and signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1.clinically significant cognitive impairment,Mini Mental State Examination (MMSE)<24; 2.MRI contraindications; 3.a history of a neurological disorder aside from PD; 4.orthopedic problems;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment, Beijing version;Mini-Mental State Examination, MMSE;Unified Parkinson's Disease Rating Scale, UPDRS;Berg Balance Scale, BBS;Mini Balance Evaluation Systems Test, Mini-BESTest;speed;stride;The Parkinson's Disease Questionnaire, PDQ-39;serial reaction time, SRT;rs-fMRI;EEG; | — |
Countries
China
Contacts
Public ContactLin Meng
Academy of Medical Engineering and Translational Medicine, Tianjin University
Outcome results
None listed