septic shock
Conditions
Interventions
Sponsors
Department of Critical Care Medicine, Renmin Hospital of Wuhan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1)age >= 18 years old; (2) it meets the diagnostic criteria for septic shock according to the International Guidelines for Management of Sepsis and Septic Shock(2016); (3) invasive mechanical ventilation is required; (4)obtain informed consent from patients or their family members
Exclusion criteria
Exclusion criteria: (1) patients who have undergone invasive mechanical ventilation and used sedative drugs at admission; (2) those with other types of shock; (3) pregnant and nursing women ; (4) death is expected in the short term; (5) those using muscle relaxants; (6)patients with alcoholism or mental disorders or severe cognitive impairment; (7) patients with neuromuscular disorders; (8) patients with severe liver and kidney insufficiency; (9) patients with hypotension whose hemodynamics are still unstable maintained with vasoactive drugs; (10) Patients with acute myocardial infarction and severe heart failure (NYHA grade IV); (11) Patients who are allergic to remiazolam toluenesulfonate, propofol and midazolam.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| RASS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| time to reach target sedation level;The rate of reaching target sedation within 8 hours of sedation treatment;Total amount of vasoactive drugs used within 8 hours of sedative treatment;Adverse reaction rate;Waking time;MODS incidence;Delirium incidence;Time of invasive ventilation;case fatality rate in ICU,;blood gas; | — |
Countries
China
Contacts
Public ContactChangyong Wang
Department of Critical Care Medicine, Renmin Hospital of Wuhan University
Outcome results
None listed