knee osteoarthritis
Conditions
Interventions
Group A:intra-articular injection placebo
Group B:intra-articular injection platelet-rich plasma
Group C:Tai Chi combined with intra-articular injection placebo
Group D:Tai Chi combined with intra-articular injection platelet-rich plasma
Sponsors
Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) meet the KOA diagnosis criteria; (2) aged 50–75 years; (3) Kellgren-Lawrence (KL) grade ? to III based on radiographic classification; (4) without the experience of TC; (5) volunteer to take part in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) have the history of trauma, ligament damage, fracture, or surgery on the knee within 12 months, causing pain or functional problems; (2) have severe cardiovascular disease, damage of liver and kidney function, immune deficiency, diabetes mellitus, and blood diseases; (3) have other acute or chronic disorders or psychiatric conditions that will affect physical or cognitive functions; (4) have received medication or relevant intra-articular injection within the last 3 months; (5) have involved in any study related to exercise program within the last 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Western Ontario and McMaster Universities Osteoarthritis Index;Referral rate;Retention rate;Drop-out rate;Inflammatory factor in the synovial fluid (IL-1 ß, IL-6 and TNF-a); | — |
Secondary
| Measure | Time frame |
|---|---|
| step length;step velocity;single support time;Knee ROM;knee adduction moment;36-Item Short Form Health Survey;Timed Up and Go test; Inflammatory factor in the venous blood (IL-1 ß, IL-6 and VEGF ); | — |
Countries
China
Contacts
Public ContactYang Kun
Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine
Outcome results
None listed