apnea
Conditions
Interventions
control group:Caffeine citrate drug treatment
Experimental group ?:Treatment with five-tone therapy combined with caffeine citrate (the first dose of caffeine citrate is 20mg/kg, and 5mg/kg is changed after 24 hours, once a day)
Experimental group ?:Treatment with five-tone therapy combined with caffeine citrate (the first dose of caffeine citrate is 20mg/kg, and 10mg/kg is changed after 24 hours, once a day)
Sponsors
Jiangxi Maternal and Child Health Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Giving birth in Jiangxi Provincial Maternal and Child Health Care Hospital; (2) need non-invasive respiratory support; (3) The baby is born between 28-32 weeks for gestational age and has a birth weight of less than 1500g
Exclusion criteria
Exclusion criteria: (1) severe asphyxiation; (2) need invasive mechanical ventilation support; (3) Accompanied by severe congenital malformations, especially ear malformations, hereditary metabolic diseases, chromosomal or genetic abnormalities; (4) severe intracranial hemorrhage or neuromuscular disease; (5) Hearing dysfunction (otoacoustic emission does not pass through both ears); (6) TORCH infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the incidence of apnea at 34 weeks' gestation;Number of apnea occurrences per day;Time for apnea to disappear;Timefor noninvasive assisted ventilation;Time of treatment with oxygen;Time of treatment with caffeine citrate;duration of hospitalization; | — |
Secondary
| Measure | Time frame |
|---|---|
| incidence of tachycardia;incidence of feeding intolerance;incidence of necrotizing enterocolitis;incidence of retinopathy of prematurity;Incidence of bronchopulmonary dysplasia;Incidence of intraventricular hemorrhage;Incidence of white matter malacia; | — |
Countries
China
Contacts
Public ContactQin Luo
Jiangxi Maternal and Child Health Hospital
Outcome results
None listed