laryngopharyngeal reflux
Conditions
Interventions
Case group before treatment:not have
Case group after treatment (Esomeprazole was administered orally):None
validation group:not have
Sponsors
PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 78 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria is as follows: (1)ENT outpatients having complaints of continuous throat clearing, hoarseness, articulation fatigue, sore throat, chronic cough, dyspnea and other symptoms lasting for more than 3 months with RSI more than 13 whose symptoms disappear or ease (RSI less then 13 or less than 50% of the initial score) after taking esomeprazole orally for 8 weeks were considered case group. (2) The patients are first episode. (3) Their age range from 18-78 years. (4) Patients have no serious systemic disease or mental disease. (5) They agree to sign the written informed consent. (6) The patients do not have habits of taking probiotics and prebiotics.
Exclusion criteria
Exclusion criteria: patients with any of the following diseases should be excluded: (1) Patients sufferring from diabetes, hypertension, malignant tumors, respiratory diseases, endocrine diseases, heart diseases, arrhythmia, cardiogenic chest pain, cerebrovascular accidents, upper gastrointestinal diseases, upper abdominal operations or other serious systemic diseases; (2) Patients taking medicine that might impact autonomic nervous function, such as cholinergic agonists or antagonists, adrenergic agonists or antagonists, neuromuscular blockers drugs, antipsychotics, immunomodulators, and prostaglandins; (3) Patients with habits of long-term smoking or alcohol abuse; (4) Patients drinking beverages containing caffeine or alcohol within 24 hours before the experiment and those with major changes in diet; (5) Female during menstruation, pregnant or lactating. (6) Patients taking medicine of antibiotics and proton pump inhibitors within one month. (7) Patients with upper respiratory tract infection and recovery time less than 2 weeks. (8) Patients with acute oral infection. (9) Patients having to take medicine that will influence the judgment of test result during the experiment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Salivary microbiota; | — |
Countries
China
Contacts
Public Contactzhang yanping
PLA General Hospital
Outcome results
None listed