coronavirus pneumonia (COVID-19)
Conditions
Interventions
KFX:Best treatment+Kangfuxin liquid20ml,tid
palcebo:Best treatment+placebo20ml,tid
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
14 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1) Age 20-80, male or female; 2) positive SARS-CoV-2 test result within 3 weeks; 3) HRCT meeting the manifestations of viral pneumonia (judged by the investigator) and meeting any of the following criteria: Shortness of breath, respiratory rate (RR) =30 times/min; At rest, SpO2 50% within 24~48 hours; PaO2/FiO2 <=300mmHg(1mmHg=0.133kPa) 4)The patient must be able to fully understand the informed consent form and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1)Patients who have known allergies to any of the components used in the formulation of the interventions; 2)Patients with a history of asthma or ongoing asthma attacks; 3)Patients with critical novel coronavirus pneumonia (COVID-19); 4)Female who is pregnant or breast-feeding or plan to be pregnant within this study period; 5)The investigator considers it inappropriate to participate in the study .
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Interval and proportion of randomization to clinical improvement; | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of subjects whose disease progressed to critical illness at day 14 and 28;All-cause mortality of subjects at day 28;the time interval between randomization and discharge; the ratio of NIAID - OS score from baseline to improve two or more subjects at day 28;Proportion of subjects with HRCT showing significant absorption of lung inflammation during treatment and/or at EOT;the rate of AE ,SAE;Changes in vital signs, physical examination, laboratory examination, 12-lead electrocardiogram, etc; | — |
Countries
China
Contacts
Public ContactWei min Li
West China Hospital, Sichuan University
Outcome results
None listed