Intracranial atherosclerotic disease
Conditions
Interventions
Case group:Best medicine treatment
Sponsors
The Second Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Age >18-85 years 2.All symptomatic patients referred to the inpatient/outpatient clinical service of the Department of Neurology at the Second Affiliated Hospital of Nanjing Medical University with a diagnosis of intracranial atherosclerosis 3.CTA/MRA/DSA imaging findings confirmed the presence of moderate to severe stenosis >50% in =1 segment of superior ICA, A1-A2 ACA, M1-M2 MCA, and distal vertebrobasilar artery. 4.Symptomatic patients, defined as an association between intracranial stenosis and perfusion/thromboembolic ischemia-related symptoms in the corresponding vascular region, based on neurological examinations (TIAs/ stroke) and/or acute/subacute infarction documented on MR-DWI within 7 days of onset.
Exclusion criteria
Exclusion criteria: 1.Standard contraindications to MRI: claustrophobia, metallic implants, pacemaker, compromised kidney function (GFR 85 years 3.Multiple or serious medical conditions, or history of multiple drug allergies Other confounders of neuro-functional exams, i.e. Alzheimer's Disease or dementia. 4.Severe >70% cervical carotid or vertebral artery proximal stenosis, or tandem intracranial stenosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plaque stability; | — |
Countries
China
Contacts
Public ContactWu Yanfeng
The Second Affiliated Hospital of Nanjing Medical University
Outcome results
None listed