Changes of postoperative immune function and postoperative pain
Conditions
Interventions
Group SF:Use sufentanil to configure analgesia pump
Group OC:Use oxycodone to configure analgesia pump
Sponsors
Quanzhou First Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: a. Patients who plan to undergo endoscopic lung wedge resection under general anesthesia of tracheal intubation; b. Age 18-65, regardless of gender; c. Body mass index (BMI): 18.5-28; d. American Society of Anesthesiologists (ASA): I-III; e. Subjects voluntarily participated in the trial and signed the informed consent form.
Exclusion criteria
Exclusion criteria: a. Subjects explicitly refused to participate in this study; b. Allergies to opioids and drug excipients; c. Use barbiturates, sedative hypnotics, phenothiazines, antipsychotics, antidepressants, rifampicin, voriconazole, antihypertensive drugs, etc; D. Suspected of abuse of narcotic analgesics or sedatives and alcoholics; e. Have a history of serious heart, brain, lung, liver, kidney or metabolic diseases (such as hypothyroidism), a history of mental illness, and a history of myasthenia gravis; f. ECG: heart rate100 times/min or serious arrhythmia; Echocardiography showed: EF value<50%; g. Acute respiratory tract infection within two weeks without cure; h. Pregnant and lactating women; i. Subjects who are considered unsuitable by other researchers to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Static VAS score;Dynamic VAS score;Whole blood T-lymphocyte subsets CD4+;Whole blood T-lymphocyte subsets CD8+;Percentage of NK cells;IL-2; | — |
Secondary
| Measure | Time frame |
|---|---|
| Recovery analgesia rate within 48 hours;48h dosage;Number of press and invalid press within 48 hours;Respiratory depression;Delayed awakening;Incidence rate of other side effects; | — |
Countries
China
Contacts
Public ContactWenqin Xie
Quanzhou First Hospital Affiliated to Fujian Medical University
Outcome results
None listed