Overactive Bladder Syndrome
Conditions
Interventions
Vitamin D supplementation group:Supplementation with oral vitamin D preparations
Standard urotherapy group:Dietary instruction, behavioral training, bladder training
Sponsors
Department of Urology, Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
4 Years to 18 Years
Inclusion criteria
Inclusion criteria: (1) Children older than 4 years of age with a diagnosis of OAB seen at the outpatient urology clinic of the Children's Hospital of Chongqing Medical University (diagnosis follows the latest ICCS recommendations). (2) Children with a serum vitamin D level of less than 35 ng/ml as indicated by the laboratory results of our hospital. (3) The child's guardian has been informed of the nature of the study, understands the provisions in the protocol, can ensure compliance, and has signed an informed consent form.
Exclusion criteria
Exclusion criteria: (1) Those with a combination of other urological abnormalities or serious diseases (e.g. hypospadias, cryptorchidism, posterior urethral valves, vesicoureteral reflux, neurogenic bladder, urological tumours, urinary stones, bladder and urethral injuries, etc.). (2) Combined neurological disorders (e.g. epilepsy, spinal cord injury, spinal cord dysplasia, spinal cord embolism syndrome, multiple sclerosis, autism spectrum disorder, etc.) (3) Those with a combination of severe heart disease, abnormal liver or kidney function, lung disease, skeletal deformities, severe gastrointestinal disease, or inherited metabolic disorders (4) Those with a history of gastrointestinal surgery and urinary tract surgery (5) Those with dry stools and chronic constipation. (6) Those who are taking anticonvulsant and antiepileptic drugs, hormones, anti-tuberculosis drugs. (7) Previous history of hypercalcemia, hyperphosphatemia with renal rickets. (8) History of unexplained haematuria and urinary tract infection within the last 1 year. (9) History of allergy or allergic disease to vitamin D preparations. (10) Participation in other clinical studies at the time of consultation or during follow-up of other clinical studies. (11) Unwillingness to participate in this study or poor compliance with follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pediatric lower urinary tract symptom score;Overall symptom improvement score;bladder diary;Urinary frequency, urinary urgency, urinary incontinence, maximum urinary output;Maximum urinary urgency score;urinary urgency score;Drug-related adverse reactions;Serum vitamin D levels; | — |
Countries
China
Contacts
Public ContactXing Liu
Children's Hospital of Chongqing Medical University
Outcome results
None listed