Cervical cancer
Conditions
Interventions
Test group:Paclitaxel-albumin+carboplatin+radiotherapy
Sponsors
Yiyang Center Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Patients diagnosed as cervical cancer by pathological biopsy; 2) The clinical stage is ? b~? a (FIGO 2018 cervical cancer stage); 3) KPS score = 70; 4) There are measurable primary target lesions by MRI or CT; 5) Expected life = 6 months; 6) Age 18-75; 7) Hematology, liver and kidney functions were basically normal (hematology: absolute neutrophil count = 1500/ul, platelet = 100000/ul, hemoglobin = 9g/dl; renal function: serum creatinine = 1.5 times the upper limit of normal value; liver function: serum total bilirubin = 1.5 times the upper limit of normal value, aspartate aminotransferase = 1.5 times the upper limit of normal value, alanine aminotransferase = 1.5 times the upper limit of normal value, alkaline phosphatase = 1.5 times); 8) The patient signed the consent form for clinical study, interventional therapy, chemotherapy and radiotherapy.
Exclusion criteria
Exclusion criteria: 1) patients who have contraindications of interventional therapy, radiotherapy and chemotherapy, and allergy to albumin paclitaxel, carboplatin and cisplatin; 2) Patients with severe diseases such as gastrointestinal bleeding and perforation; 3) Pregnant and lactating women; 4) patients with a second malignant tumor; 5) Serious liver and kidney diseases, respiratory diseases or chronic diseases such as uncontrollable diabetes and hypertension; 6) Patients with mental disorder; 7) The evaluation criteria of common adverse reactions were>2 grade for severe clinical infections in active stage; 8) Patients who have a history of organ transplantation; 9) Alcohol or drug abuse; 10) No civil capacity or limited civil capacity.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| ORR;DCR;OS;QOL; | — |
Countries
China
Contacts
Public ContactLi Xiantao
Yiyang Center Hospital
Outcome results
None listed