Major Depressive Disorder
Conditions
Interventions
Treatment Group:tACS was treated 20 times, combined with esitalopram oxalate 10mg-20mg daily for 4 weeks
Control Group:TACS pseudo-stimulation treatment for 20 times, combined with esitalopram oxalate 10mg-20mg daily for 4 weeks.
Sponsors
Beijing Anding Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1) Meet the DSM-V diagnostic criteria for major depressive episodes (single episode or recurrence); 2) Outpatients aged 18-55 years old, male or female; 3)HAMD-17 score =17 points, and HAMD-17 item 1 (depressed mood) score =2 points; 4) Not receiving treatment of MECT/ECT, TMS, tDCS, etc. one month before enrollment; 5) Not receiving treatment of antidepressant for this episode; 6) Have understood all Study content and sign informed consent.
Exclusion criteria
Exclusion criteria: 1) Meet the DSM-IV diagnosis of other psychiatric disorders; 2) Impaired skin integrity at electrode placement site, allergic to electrode gel or adhesive; 3) With implanted electronic stimulator 4) HAMD-17 item 3 (suicide ) Score = 3; 5) Patients with previous suicidal behavior or existing strong suicidal ideation; 6) Those who participated in any other clinical trial within 1 month before baseline; 7) Previous manic or hypomanic episodes; 8 ) Patients with severe or unstable organic diseases; 9) Women who are pregnant and breastfeeding, patients who cannot take appropriate contraceptive measures during the trial; 10) Have seizures, epilepsy, hydrocephalus or central nervous system History of tumor, acute brain injury and infection; 11) Patients who are deemed inappropriate by the investigator; 12) Researchers who participated in this study or their immediate family members;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction rate of HAMD-17 total score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Each factor score of HAMD-17;CGI;GAD-7;QIDS-SR16;PSQI;Electroencephalogram;MRI; | — |
Countries
China
Contacts
Public ContactGang Wang
Beijing Anding Hospital, Capital Medical University
Outcome results
None listed