acute hypoxic respiratory failure
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Acute onset within 1 week of known clinical impairment (i.e. risk factors) or new/aggravated respiratory symptoms within 1 week (unknown clinical impairment); 2. Continuous use of HFNC(Flow=30L/min) for more than 12 hours; 3. Acute hypoxic respiratory failure (PaO2/FiO2=300 mmHg, PaCO2= 45mmHg) 4. Sign the informed consent form
Exclusion criteria
Exclusion criteria: Main exclusion criteria: 1. Acute exacerbations of severe asthma or chronic respiratory failure (including chronic obstructive pulmonary disease, interstitial lung disease, or other underlying chronic respiratory diseases); 2. Cardiogenic pulmonary edema 3. Enrolled patients requiring emergency endotracheal intubation (evaluated by clinicians, including life-threatening hypoxemia, cardiac or respiratory arrest, etc.); 4. Patients need selective intubation 5. Patients with HFNC after extubation; 6. Patients who refuse endotracheal intubation Secondary exclusion criteria 1. Patients who refused endotracheal intubation during study period;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intubation rate within 7 days after inclusion; | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of patients meeting the diagnostic criteria for ARDS before and after endotracheal intubation;28-day mortality;Incidence of organ dysfunction;Length of ICU stay; | — |
Countries
China
Contacts
Public ContactChen Hui
The First Affiliated Hospital of Soochow University, Soochow University
Outcome results
None listed