Glucose metabolism abnormality
Conditions
Interventions
Experimental group 1:Take raw American ginseng root powder.
Experimental group 2:Take American ginseng root powder treated at high temperature
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
30 Years to 50 Years
Inclusion criteria
Inclusion criteria: Meet all of items 1-3 and any of items 4 or 5. 1) Age: 30-50 years old 2) Gender is not limited, and women are required to be premenopausal. 3) BMI:18.5-27.9Kg/m2 4) Meet the diagnostic criteria of prediabetes (according to the diagnostic criteria of prediabetes specified by ADA in 2022) I. impaired fasting (IFG):5.6mmol/L=FPG=6.9mol/L or Ii. Impaired glucose tolerance (IGT):7.8mmol/L=75 g OGTT = 11.Ommol/L or Iii. Glycosylated hemoglobin: 5.7%-6.4% 5) Newly diagnosed diabetes: type 2 diabetes is diagnosed within one year, but daily fasting blood glucose should be = 9.0mmol/L.
Exclusion criteria
Exclusion criteria: Meeting any of the following conditions shall be excluded: 1) take any hypoglycemic drugs, lipid lowering drugs, antihypertensive drug; Take insulin. 2) Human immunodeficiency virus -1 infection and malignant tumor; Active cardiovascular, renal, pulmonary, liver, blood, digestive, neurological or psychiatric disorders; Recent (within 4 weeks) acute respiratory symptoms. 3) Any drug that is considered likely to interfere with the assessment (e.g., other herbal products, immunosuppressants, anticoagulants), or a history of allergy to ginseng products or other adverse reactions. 4) Pregnant or lactating women. 5) allergic constitution and allergic to a variety of drugs. 6) circadian rhythm disorder, such as shift workers. 7) In the discretion of the investigator, the subject suffers from any disease or other condition that may jeopardize his or her safety or affect adherence to the protocol that is not eligible for participation in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HbA1c;fasting blood-glucose;fasting insulin;post-meal blood glucose;Postprandial insulin; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood fat;sex hormone;thyroid hormone;Cortisol;Cytokines;Nottingham health profile;reactive oxygen species; | — |
Countries
China
Contacts
Public ContactShi Bingyin
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed