Parkinson's disease, dementia, anxiety/depression, insomnia disorders
Conditions
Interventions
Gold Standard:The diagnosis of PD is based on the clinical diagnostic criteria for Parkinson's disease introduced by the International Movement Disorder Society (MDS) in 2015
AD is based on the Alzheimer's Association (NIA-AA) criteria of the National Institute on Aging in 2011
anxiety disorders and depression disorders The diagnosis was based on the tenth edition of the International Statistical Classification of Diseases and Related Health Problems (ICD-10) criteria
the third edition of the International Classification of Sleep Disorders (ICSD-3) was used for insomnia.
Index test:Magnetic resonance neurite direction dispersion and density imaging, functional near-infrared spectroscopy imaging technology, ear EEG, polysomnography, heart rate variability, virtual real
Sponsors
The Second Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), anxiety/depression disorder, insomnia disorder and age-matched healthy people hospitalized in the Department of Neurology of the Second Affiliated Hospital of Dalian Medical University were selected.
Exclusion criteria
Exclusion criteria: 1. People with pacemaker implantation; 2. Have a history of brain surgery; 3. There are metal implants or other foreign bodies in the brain; 4. Cochlear implant recipients; 5. Patients with a history of epileptic seizures or a family history of epilepsy; 6. Acute traumatic brain injury, cerebral hemorrhage, cerebral infarction patients; 7. Patients with a history of organic diseases such as intracranial infection; 8. Patients who are pregnant, breastfeeding, or have the possibility or plan of pregnancy; 9. Participating in other clinical trials; 10. Acute vertigo; 11. Severe visual impairment or corrected vision can not see the cursor clearly, color blindness, color weakness, strabismus, amblyopia, congenital nystagmus; 12. Taking central sedative drugs, antiepileptic drugs and other drugs affecting the vestibular system 72 hours before the examination; 13. In the resting state, there is obvious tremor in the head. 14. Cannot perform CT or MRI examination for any reason, or cannot cooperate with clinical assessment, laboratory or imaging assessment follow-up (such as severe dementia or mental disorder, severe metabolic disease, any advanced disease leading to life expectancy < 6 months) wait); 15. The researchers judged that they are not suitable for participating in this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intracellular volume fraction;isotropic volume fraction;Directional Dispersion Index;mean oxyhemoglobin concentration;scanning range;scaning latency;saccadic velocity; | — |
Countries
China
Contacts
Public ContactLin Yongzhong
The Second Hospital of Dalian Medical University
Outcome results
None listed