Common COVID-19 pneumonia
Conditions
Interventions
Group 1:Normal saline intravenous pumping
Sponsors
Medical Ethics Committee of Shanghai Fourth People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Common COVID-19 pneumonia; 2. Age >= 65years old; 3. Voluntarily sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Severe liver dysfunction (Child-Pugh class C); Severe renal insufficiency (requiring dialysis); 2. Unable to complete the prone position (patients with hemodynamic instability, severe obesity (BMI > 40 kg/m2), pregnant women, or patients with spinal fracture, esophageal surgery, high risk of pressure ulcers, etc.); 3. Inability to ventilate in prone position in patients with a mental disorder; 4. Left ventricular ejection fraction < 30%, sick sinus syndrome, severe sinus bradycardia (<50 beats/min), or atrioventricular block grade II or higher without a pacemaker; 5. Participated in another clinical trial within 3 months before enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of completion of prone position ventilation for cumulative 9 hours per day; | — |
Secondary
| Measure | Time frame |
|---|---|
| Completion rate of 12-hour duration of prone position ventilation;Rate of conversion to severe pneumonia;Hemodynamic indexes (Blood pressure, heart rate);Number of vasoactive drug interventions;Improvement of infection indicators (CRP, IL-6, PCT, blood routine);Improvement of SpO2;Rate of tracheal intubation and mortality during hospitalization;30-day mortality;Length of stay;Oxygenation index;normal tissue complication probability; | — |
Countries
China
Contacts
Public ContactXiong Lize
Shanghai Fourth People's Hospital affiliated to Tongji University
Outcome results
None listed