sepsis
Conditions
Interventions
Control group:10%Glucose solution
Experimental group:Calcium
Risk factors Group:Nothing.
Prognostic group:Nothing.
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. The first and second stages: adult sepsis patients admitted to the ICU. Diagnostic criteria for sepsis: According to the Sepsis 3.0 standard, infection + SOFA score >= 2 points; 2. The third stage: Adult patients with sepsis and severe hypocalcemia admitted to the ICU. Diagnostic criteria for sepsis: According to the Sepsis 3.0 standard, infection + SOFA score >= 2 points. Severe hypocalcemia standard: serum ionized calcium level < 1.0 mmol/L.
Exclusion criteria
Exclusion criteria: 1. The first and second stages: those who have one of the following conditions are excluded from this study: the duration of sepsis when admitted to the ICU is > 48 hours; calcium supplementation, albumin, massive blood transfusion or blood purification treatment are given 72 hours before admission to the ICU; pregnant and lying-in women ; acute pancreatitis; history of chronic renal insufficiency; parathyroidectomy; history of thyroid surgery; patients with severe trauma or massive bleeding; 2. The third stage: Those who have one of the following conditions are excluded from this study: the duration of sepsis when entering the ICU is > 48 hours; calcium supplementation, albumin, massive blood transfusion or blood purification treatment are given 72 hours before entering the ICU; pregnant women; acute pancreatitis; history of chronic renal insufficiency; parathyroidectomy; history of thyroid surgery; patients with severe trauma or massive bleeding; patients expected to die within 48 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| hospital mortaliy; | — |
Secondary
| Measure | Time frame |
|---|---|
| mortaliy of 28d;length of ICU stay;length of ICU stay;Mechanical ventilation time;Time of vasoactive drug use;SOFA of Day 7;Blood transfusion volume; | — |
Countries
China
Contacts
Public ContactLei Huang
Peking University Shenzhen Hospital
Outcome results
None listed