Breast Cancer
Conditions
Interventions
Group 1:receive pegfilgrastim 24 hours after chemotherapy
Group 2:receive pegfilgrastim 48 hours after chemotherapy
Group 3:receive pegfilgrastim 72 hours after chemotherapy
Sponsors
Guangdong Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18-70 years old; 2. Pathologically diagnosed as breast cancer; 3. Patients who can receive the scheduled chemotherapy regimen as scheduled, and the chemotherapy regimen is a middle-to-high-risk febrile neutropenia regimen.
Exclusion criteria
Exclusion criteria: 1. There are currently other diseases that cause severe bone pain (referring to non-breast cancer and related treatments that cause bone pain > 5 points in the digital analog scale of 0-10 points); 2. Allergic to chemotherapy drugs or Shengbai injection or contraindicated in use; 3. Previously used Shengbaizhen.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The area under the curve (AUC) for worst bone pain for days 1 through 5 (day 1 is defined as the day of pegfilgrastim administration); | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of bone pain;Incidence of severe bone pain;Duration of bone pain;Impact of bone pain on daily life and other aspects;Incidence of febrile neutropenia;Leukocyte count;Patient-reported outcomes; | — |
Countries
China
Contacts
Public ContactKun Wang
Department of Breast Cancer, Guangdong Provincial People's Hospital
Outcome results
None listed