Cognitive function of the elderly patients after hip replacement
Conditions
Interventions
Experimental group:Intravenous administration of esketamine 0.3 mg/kg before induction of anesthesia
Control group:Ultrasound guided fascia iliaca compartmentblock
Sponsors
Affiliated Hospital of Hebei University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Those who meet the indications for hip replacement surgery, undergo elective total hip replacement surgery, and sign an informed consent form for anesthesia; 2. Patients with anesthesia grade I-III of the American Society of Anesthesiologists; 3. Operation time <= 3 hours; 4. Body mass index < 30 kg/m2.
Exclusion criteria
Exclusion criteria: 1. Those who refuse to sign the informed consent form; 2. Patients with severe cardiopulmonary disease; 3. Patients with severe hypertension; 4. Patients with intracranial space occupying and intracranial hypertension; 5. Patients with glaucoma and hyperthyroidism; 6. Patients with contraindications to surgery and anesthesia; 7. Preoperative nervous system diseases or mental illness history or combined with dementia and other cognitive dysfunction diseases; 8. Long-term use of sedative and analgesic drugs; 9. Those who are allergic to the experimental drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination Score;Inflammative factors; | — |
Countries
China
Contacts
Public ContactZhao Chendi
Affiliated Hospital of Hebei University
Outcome results
None listed