Allergic rhinitis
Conditions
Interventions
group 1:cryoablation of the posterior nasal nerve
group 2:cryoablation of the posterior nasal nerve and anterior ethmoidal nerve
Sponsors
Shanghai East Hospital, School of Medicine, Tongji University
Eligibility
Sex/Gender
All
Age
21 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 21-65 years old, gender is not limited; 2. For patients with clearly diagnosed AR, the diagnostic criteria refer to the Guidelines for the Diagnosis and Treatment of Allergic Rhinitis in China (2022): (1) Symptoms: 2 or more symptoms such as paroxysmal sneezing, clear watery nasal discharge, nasal itching, and nasal congestion, which last or accumulate for more than 1 hour every day, and may be accompanied by eye symptoms such as tearing, itchy eyes, and red eyes; (2) Signs: Pale nasal mucosa, edema, and watery nasal discharge are common; (3) Allergen detection: at least one allergen SPT and/or serum-specific IgE positive, or nasal challenge test positive; (results within one year are all valid); 3. Symptom onset >= 4 days/week, and >= 4 consecutive weeks; 4. Moderate-severe AR, that is, the symptoms are severe or severe, and have a significant impact on the quality of life (including sleep, daily life, work and study); 5. rTNSS >= 8 points within 12 hours, of which the nasal congestion score >= 2 points; 6. Patients and guardians are informed and agree to participate in the research.
Exclusion criteria
Exclusion criteria: 1. Those who have taken steroids in the past 2 weeks and antihistamines or external steroids in 1 week; 2. Nasal space-occupying lesions and structural abnormalities, including but not limited to: nasal polyps, nasal masses, meninges-encephalocele, congenital nostril atresia, congenital pyriform stenosis, maxillary frontal process thickening and inward shifting, deviated nasal septum, perforated nasal septum, pneumatization of nasal middle nail, etc.; 3. Combining with asthma attacks; 4. Patients with serious primary diseases such as cardiovascular, cerebrovascular, liver, kidney, hematopoietic system; 5. Those who had nasal sinus surgery in the past, resulting in obvious changes in the anatomical structure of the back of the nose; 6. Those who have received head and neck radiation therapy in the past; 7. Those with active or chronic sinus infection; 8. Those who have active coagulation disorder or are receiving anticoagulant therapy and cannot safely stop the drug for 2 weeks; 9. People with dry eye syndrome in the past; 10. Pregnant, lactating or pregnant women; 11. Active smokers, or continuous smokers in the past 6 months; 12. Any physical condition that the researcher believes may seriously affect the research results or increase the risk.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| reflective Total Nasal Symptom Score 3 months after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| rTNSS at 7 days, 1 month, 6 months, and 12 months after surgery;Rhinoconjunctivitis Quality of Life Questionnaire; | — |
Countries
China
Contacts
Public ContactZhaoxin Ma
Shanghai East Hospital, School of Medicine, Tongji University
Outcome results
None listed