extrapulmonary tuberculosis
Conditions
Interventions
Gold Standard:1. Diagnostic criteria for pulmonary tuberculosis (Health Industry Standard of the People's Republic of China WS288-2017): (1) Sputum smear positive pulmonary tuberculosis diagnosis who
b ) 1 sputum smear positive for acid-fast bacilli, and at the same time meet any of the chest imaging characteristics of pulmonary tuberculosis
c) 1 sputum smear positive for acid-fast bacilli, and 1 sputum smear positive for mycobacteria. (2) Only mycobacterial isolation and culture positive tuberculosis diagnosis is consistent with any one
(3) Molecular biological examination positive tuberculosis diagnosis is consistent with pulmonary tuberculosis Any one of the chest imaging features and a positive tuberculosis molecular biology test
(4) positive lung histopathological examination for pulmonary tuberculosis diagnosis lung histopathology showed granulomatous inflammation, and tuberculosis DNA positive or positive culture
2. Diagnostic criteria for lymph node tuberculosis: lymph node enlargement confirmed by ultrasound, histopathology of lymph node aspiration or surgical biopsy showed granulomatous inflammation with or
3. Diagnostic criteria for latent tuberculosis infection: no signs of active tuberculosis, and a positive interferon-gamma release assay (IGRA), or a positive tuberculin skin test.
Index test:Specific sRNA of mycobacterium tuberculosis in peripheral blood.
Sponsors
The Third People's Hospital of Shenzhen
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years; 2. Bacteriologically or pathological confirmed pulmonary tuberculosis and extrapulmonary tuberculosis, initial treated, from whom bacteriological and pathological specimens can be obtained; 3. Anti-tuberculosis treatment has not been started; 4. The patients agree to participate in the study and complete the treatment course and data collection within the study.
Exclusion criteria
Exclusion criteria: 1. Serious dysfunction of heart, liver, kidney and other complications, which affected the application and effect of anti-tuberculosis drugs and the completion of the course of treatment; 2. Severe immune deficiency or is being treated with biological agents.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Identification of mycobacterium tuberculosis peripheral blood sRNA markers for diagnosis of extrapulmonary tuberculosis.; | — |
Countries
China
Contacts
Public ContactWenying Gao
The Third People's Hospital of Shenzhen
Outcome results
None listed