Early onset ovarian insufficiency
Conditions
Interventions
Early onset ovarian insufficiency group:Pregnancy promoting needle method
Healthy people group:None
Sponsors
Shandong Provincial Third Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1.POI: (1) Aged 25U/L at least twice (interval > 4 weeks). If the above three criteria are met, premature ovarian insufficiency can be diagnosed. 2. Healthy people: (1) Aged 18-40 years; (2) Normal ovarian function; (3) Normal immune function, no immune disease; (4) The patient is informed and signs the informed consent.
Exclusion criteria
Exclusion criteria: 1. Congenital anomalies of reproductive organ development, patients with bilateral ovariectomy; 2. Endocrine diseases such as polycystic ovary syndrome, hyperprolactinemia, hyperandrogenemia, hypothyroidism, and chronic Hypoadrenocorticism affect ovulators; 3. Those with serious cardiovascular, hepatic, renal, malignancies, haematopoietic and psychiatric disorders combined.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Menopausal symptom score;Follicle-stimulating hormone;Luteinizing hormone;Eestradiol;CD4+T;CD8+T;Treg cell; | — |
Secondary
| Measure | Time frame |
|---|---|
| Transforming growth factor beta 1;Interferon;Forkhead transcription factor; | — |
Countries
China
Contacts
Public ContactBai Tianyu
Shandong Provincial Third Hospital
Outcome results
None listed