Intraabdominal candidiasis
Conditions
Interventions
Index test:Quantitative real-time PCR (qPCR) based on double-layer millipore array filter membrane filtration pretreatment
Sponsors
Department of Intensive Care Medicine, Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. ICU patients aged >=18 years; 2. The clinical supervisor determines the presence of spontaneous peritonitis, secondary peritonitis, type III peritonitis, or abdominal abscess; 3. Peritoneal drainage fluid can be obtained through intraoperative drainage tube placement or peritoneal puncture fluid can be obtained directly; 4. IAC is high-risk. IAC high risk is defined as having any of the following: (1) Digestive tract perforation (onset > 24 hours without treatment or recurrence); (2) Repeated abdominal surgery (>=2 times within 30 days); (3) Suspected or confirmed anastomotic fistula after surgery; (4) Multi-site candida colonization (>=2 sites); (5) Acute severe necrotizing pancreatitis; (6) Septic shock (>=1 hour on vasoactive drugs); (7) Antibiotics were used for >=7 days prior to ICU admission.
Exclusion criteria
Exclusion criteria: 1. The patient or his authorized client refuses to sign the informed consent; 2. Patients with granulocytosis; 3. HIV infection; 4. The drainage tube is placed for more than 24 hours; 5. The study has been included in this admission cycle; 6. Complete case data are not available.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Results of qPCR assay based on double-layer microporous array filter pretreatment;Sensitivity;Specificity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ascites ordinary smear (Candida);Ascites culture (Candida);Blood culture (Candida);Serum levels of 1, 3-beta-D glucan (G test); | — |
Countries
China
Contacts
Public ContactLi Shuangling
Department of Intensive Care Medicine, Peking University First Hospital
Outcome results
None listed