novel coronavirus pneumonia (COVID-19)
Conditions
Interventions
CoronaVac (Sinovac) vaccine recipients group:None
Comirnaty (BioNTech) vaccine recipients group:None
Unvaccinated control group:None
Sponsors
Department of Ophthalmology and Visual Sciences, the Chinese University of Hong Kong
Eligibility
Sex/Gender
All
Age
5 Years to 11 Years
Inclusion criteria
Inclusion criteria: 1. Children aged 5 to 11 years in Hong Kong who have no history of SARS-CoV-2 infection or COVID-19 vaccination. 2. In good health, no ocular or systemic diseases. 3. No immunosuppressant, anti-inflammatory or antibiotic medication or contact lenses have been used in the past 6 months. 4. No history of eye trauma or surgery. 5. OSDI score below 13 and ophthalmic examination results were normal.
Exclusion criteria
Exclusion criteria: 1. Wear contact lenses and undergo eye surgery during the study period; 2. Participants with confirmed infection or who received vaccines not specified in the study within the time period recommended by the HKSAR Government (28 and 84 days apart, with a possible delay of 1 to 2 days); 3. Body temperature >=38 degrees Celsius.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IgA/IgG/NAb titres and pro-inflammatory cytokine/chemokine levels in tears and sera;Similarities and/or differences between the data within/between different cohorts (Sinovac- CoronaVac and Pfizer-BioNTech vaccine recipients and unvaccinated controls) across/at different time points;Potential correlation and casual relation;16S rRNA microbiome profiles in conjunctival swabs;Ocular manifestations/measurements from ophthalmological examination and questionaries pre- and post-vaccination; | — |
Countries
China
Contacts
Public ContactDr BUI Huyen Trang
Department of Ophthalmology and Visual Sciences, the Chinese University of Hong Kong
Outcome results
None listed