Primary open-angle glaucoma (POAG)
Conditions
Interventions
POAG subjects group:None
Control group:None
Sponsors
Department of Ophthalmology and Visual Sciences, the Chinese University of Hong Kong; Research Grants Council
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. POAG subjects: (1) Aged 40-80 years; (2) Diagnosed with POAG as defined by: 1) Open anterior chamber angle (i.e., Shaffer's grade III or IV on dark-room gonioscopy without indentation); 2) Characteristic glaucomatous optic disc changes (i.e., notching or hemorrhage at the neuroretinal rim, narrowed neuroretinal rim and enlarged VCDR) and RNFL defects with corresponding visual field (VF) loss as shown by the Glaucoma Hemifield Test in at least one eye; 3) Absence of identifiable causes for the glaucomatous optic neuropathy, such as previous trauma, steroids use, uveitis, or rubeosis iridis; 4) Confirmed to have no diseases associated with TL shortening: any cancer, cardiovascular disease or type 2 diabetes. 2. Control subjects: (1) Aged 40-80 years; (2) Normal visual acuity; (3) No major ocular disorders except for mild senile cataract or refractive errors; (4) IOP below 21 mmHg.
Exclusion criteria
Exclusion criteria: Diseases associated with TL shortening such as cancer, cardiovascular disease and type 2 diabetes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TL and CNVs in the genome that are associated with POAG risk and progression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlations between POAG-related parameters and TL/CNVs; | — |
Countries
China
Contacts
Public ContactProf Tham Chee Yung Clement
Department of Ophthalmology and Visual Sciences, the Chinese University of Hong Kong
Outcome results
None listed